Ontario has reached a key milestone in its fight against COVID-19, having achieved its target to administer first doses to 65 per cent of Ontarians aged 18 and over ahead of schedule. The province is also preparing to roll out the eligibility for accelerated second dose appointments starting with individuals aged 80 and over, beginning May 31. If there is sufficient vaccine supply, it is anticipated that the majority of Ontario residents who choose to receive the vaccine will be able to be fully vaccinated by the end of summer. Ontario has already begun offering second doses of the AstraZeneca COVID-19 vaccine at an accelerated pace with a 10-week interval for individuals who received their first dose between March 10 to March 19, 2021. This significant progress has enabled the government to allow the provincial declaration of emergency and Stay-at-Home Order to expire on June 2. The province’s emergency brake will remain in effect, with public health measures and restrictions still in place, until the province is ready to enter Step One of Ontario’s Roadmap to Reopen. Step One may begin as early as two weeks after 60 per cent of Ontario’s adults receive at least one dose of a COVID-19 vaccine and if key indicators, such as risk of COVID-19 variants, hospitalizations, ICU occupancy and new hospital admissions and case rates continue to decline. Based on current trends in key health indicators, the province expects to enter Step One of the Roadmap the week of June 14. The province will confirm timelines closer to the expected start of Step One.